A new era of skin regeneration is here—and it’s happening on a microscopic level. With deep roots in regenerative medicine and growing clinical evidence, these microscopic messengers are helping redefine what’s possible with non-invasive treatments.
We don’t add just anything to the menu at Sana. But this? This was worth the wait. We carefully explore the landscape, notice trends, survey research, and elevate what actually works. Pairing exosomes with nano-needling was the natural next step. The results speak for themselves: stronger skin, faster healing, and glow that doesn’t fade.
Let’s take a closer look at how exosomes work, why we choose plant-based sources, and what really happens when they’re introduced into our NanoNeedling add-on.
So... What Are Exosomes?
Think of exosomes as wise, microscopic care packages or regenerators drifting around and telling your cells how to wake up, repair, and glow. These nano‑sized vesicles, roughly 30-150 nanometers in diameter, are filled with growth factors, peptides, proteins, lipids, and genetic molecules like mRNA.
While exosomes have long been used in medical therapies to promote wound healing and reduce inflammation, their arrival in skincare is opening doors to deeper, cell-level rejuvenation. They don’t work by forcing change. Instead, they encourage and support your skin’s natural healing intelligence to do what it does best.
In a 2023 split-face clinical trial, participants who received adipose-derived exosomes with microneedling saw significantly greater improvements in hydration, firmness, pigmentation, and fine lines than those who received microneedling alone over the same 12-week period. These aren’t subtle changes. They’re measurable, regenerative results that reflect a deeper kind of skin transformation.
Why Nano‑Needling and Exosomes Are Better Together
Nano-needling is gentle, non-invasive, and doesn’t break the skin barrier. Instead of needles, it uses microscopic silicone cones to create thousands of superficial micro-channels in the skin. These channels increase absorption of active ingredients and stimulate the skin without triggering inflammation or downtime.
This is where exosomes shine. When applied immediately after nano-needling, exosomes penetrate deeper into the skin and reach the cells most responsible for repair. They are laser focused. That means enhanced collagen production, faster recovery, and visible improvements in skin texture, tone, and resilience.
The glow is immediate, and the benefits build over time.
What the Science Says
We love science-backed skincare. Here’s a look at recent studies that have shaped our approach:
2023 clinical trial : A human split-face study found that micro needling paired with adipose-derived exosomes led to greater improvements in wrinkles, elasticity, hydration, and pigmentation compared to micro needling alone.
2024 in-vitro research : Plant-based exosome-like nanoparticles extracted from cucumber and wheat promoted dermal absorption, fibroblast proliferation, and production of collagen and elastin in lab studies.
- 2025 case series: In three patients treated with microneedling and exosomes derived from stem cells, pore size and texture improved visibly with results sustained for over five months.
While the field is still evolving, early research points toward a new frontier in regenerative skin treatments that are both non-invasive and highly-effective.
Why We Choose Plant-Based Exosomes
Exosomes can be derived from several sources—human, animal, or plant. At Sana, we only use plant-based exosomes, extracted from botanicals like rose, cucumber, and ginseng. Here’s why:
Stability and Consistency
Plant-derived exosomes are more stable and consistent than their animal or human counterparts, which makes formulation and results more reliable.Vegan and Clean by Nature
No human or animal involvement means they’re aligned with clean beauty principles and conscious sourcing practices.Potent Phytoactives
Botanical exosomes are rich in antioxidants, peptides, and microRNAs. These compounds support hydration, reinforce the skin barrier, protect against environmental stressors, and even boost UV defense.
We only partner with GMP-certified, lab-tested producers. Every drop is screened for purity, potency, and safety. Because at Sana, integrity is everything.
Post-Treatment: The OMAD Sheet Mask
Once your skin has received its dose of exosomes, we finish the treatment with our OMAD Mask —short for “One Mask A Day.” You’ll only need it post-treatment, and it delivers concentrated plant-based exosomes, calming ingredients, and deep hydration to help seal everything in.
This mask is like a comfort blanket for your skin. It cools redness, reinforces the barrier, and helps guide your skin into full recovery mode. It’s more than just a finishing touch. It’s the first step in your skin’s next phase of repair.
Is it Safe?
Exosomes are considered safe when sourced and applied correctly. Global research efforts continue to be ongoing in the U.S., South Korea, and across the EU to ensure safety and efficacy.
An important key lies in sourcing. A 2022 international review emphasized the essential need for standardized purification methods to ensure safety and consistency. That’s why we only source exosomes from trustworthy, credible labs that meet rigorous standards for stability, cleanliness, and transparency.
We know exactly where our exosomes come from, how they’re produced, and what they’re capable of.
Exosomes vs. Botox & PRP
Exosomes aren’t here to replace injectables like Botox or regenerative treatments like PRP, they offer something different altogether.
While Botox works by relaxing muscle movement and PRP relies on your body’s own platelets, exosomes are more like targeted activators for your skin cells. They encourage regeneration from within, tapping into the skins full potential, and they do it consistently, without needing a blood draw.
Here’s What You Can Expect:
Instant luminosity
Progressive improvements in firmness and hydration
Reduced redness and post-inflammatory hyperpigmentation
Smoother texture and smaller-looking pores
Long-term collagen and elastin support
Best results are achieved through a structured series, usually monthly or bi-monthly sessions depending on your skin goals.
The Sana Standard
Everything we do at Sana Skin Studio begins with purpose. We believe in gentle strength, regenerative power, and letting the skin heal itself with the right tools and guidance. The pairing of nano-needling and plant-derived exosomes is a reflection of that philosophy.
This treatment is precise, potent, and rooted in science.
We’re excited to bring this to our updated menu launching summer 2025. It’s skincare designed for results that last, delivered with intention, integrity, and a little Sana magic that can only be experienced once you step behind our Sana’s curtain.
Curious to Try It?
If your skin feels dull, uneven, or just not as resilient as it used to be, this treatment may be the reset, next-level glow, and long-term renewal you need.
We’d love to personalize it for you. Book online or stop by and let’s talk about what your skin needs right now—and how we can help you get there.
